Cystic Echinococcosis and Host Interleukin-2, Interleukin-9 and Interleukin-10 as Biomarkers for Evaluation of Albendazole and Praziquantel Treatment in Experimentally Infected Mice

Echinococcus granulosus sensu lato larvae cause cystic echinococcosis, a highly contagious zoonotic illness that poses worldwide threat to human health and development. The purpose of this study was determine the therapeutic effectiveness albendazole praziquantel, each alone in combination, vivo estimate serum levels interleukin-2, interleukin-9 interleukin-10 as biomarkers evaluating responsiveness praziquantel treatment experimentally infected mice. To assess efficacy vivo, mice were intraperitoneally inoculated with viable protoscolices then gavaged daily for 1 mo (15 mg/kg/d) (25 mg/kg/d), separately combination (albendazole 15 mg/kg/d 25 mg/kg/d. euthanized on d 120 experiment number, size location generated secondary hydatid cysts investigated estimated. number decreased upon drug, but decrease significant (p<0.05) isolates 2, 3, 4, 6, 8, 9 10, 2 respectively. most often organ liver (44.91 %), followed by peritoneal cavity (30.3 subcutaneous (21.1 spleen (3.29 %) lungs (0.38 %). Interleukin-2 level significantly elevated inoculating parasite isolates, whereas not altered considerably treated compared untreated control. Albendazole markedly reduced control group granulosus-infected stimulated production which is helpful elimination. These results indicate have protoscolicidal effects has additive effects.